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Ce este acidul alfa-cetoglutaric (328-50-7)?

Acidul alfa-cetoglutaric este un compus biologic care se găsește în mod natural în corpul uman. De asemenea, disponibil ca supliment alimentar, acidul alfa-ketoglutaric joacă un rol cheie în ciclul Krebs (o serie de reacții chimice utilizate pentru a elibera energia stocată). Se pretinde că suplimentele cu acid alfa-cetoglutaric oferă o varietate de beneficii pentru sănătate, inclusiv performanțe atletice îmbunătățite și metabolism îmbunătățit.

Beneficiile acidului alfa-cetoglutaric (328-50-7)

Acestea fiind spuse, câteva studii timpurii au sugerat beneficiile potențiale ale suplimentării cu acid alfa-ketoglutaric. Iată ce spun unele dintre cercetările actuale:
①Boli renale cronice
Alpha-ketoglutaric acid has been used since the late-1990s to help break down and absorb protein in people on hemodialysis who require a low-protein diet. Recent evidence suggests that it may also delay the need for dialysis in people with advanced chronic kidney disease (CKD).


Sursa de încredere

PubMed Central

Baza de date foarte respectată de la National Institutes of Health
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According to a 2017 study in the journal PLoS One, researchers identified and followed 1,483 people with advanced CKD who used an alpha-ketoglutaric acid supplement called Ketosteril. The average duration of the follow-up was 1.57 years.
Compared to a matched set of individuals who didn't take the supplement, those who did were less likely to require long-term dialysis. The benefits extended only to those who took more than 5.5 tablets per day, indicating the effects were dose-dependent.
Despite the positive findings, it is unclear what role alpha-ketoglutaric acid played in comparison to the supplement's other active ingredients. Further research is needed.

②Sănătatea gastrointestinală
Alpha-ketoglutaric acid supplements are believed to be anticatabolic, meaning that it slows or prevents or catabolism (the breakdown of tissues). By definition, a catabolic process is opposite to an anabolic process (in which tissues are built).
A 2012 study in the Italian Journal of Animal Science reported that alpha-ketoglutaric acid prevented the breakdown of the intestines in lab rats fed a protein-free diet for 14 days. Rather than experiencing damage to the finger-like villi of the intestines—the expected outcome—the rats fed alpha-ketoglutaric acid had no visible damage compared to rats that weren't.
Moreover, the rats provided the supplements were able to maintain normal growth despite the total lack of protein. Higher doses conferred to even better results.
The findings appear to support alpha-ketoglutaric acid's anticatabolic effects. In addition to its application in chronic kidney disease, alpha-ketoglutaric acid may also aid people with intestinal toxemia and malabsorption disorders like celiac disease. Further research is needed.

③Performanță atletică
By contrast, the anticatabolic effects of alpha-ketoglutaric acid appear to fall short when used for the purpose of muscle growth and athletic performance.
According to a 2012 study in the Journal of the International Society of Sports Nutrition, alpha-ketoglutaric acid had no tangible effect on either muscle strength or exercise endurance in 16 men tasked with a resistance training workout.


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PubMed Central

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For this study, half of the men were given 3,000-milligrams (mg) of alpha-ketoglutaric acid, while the other half were given a placebo 45 minutes before doing bench press and leg press exercises. The following week, the supplements were flipped, with each half getting the alternate drug.
Athletic performance was based on the total load volume (TLV) of the exercises performed in tandem with pre- and post-exercise heart rates. What these findings demonstrate is the absence of catabolic response is not the same thing as an anabolic response, especially among athletes.

Utilizează acidul alfa-cetoglutaric (328-50-7)?

In heart surgery, alpha-ketoglutaric acid is sometimes delivered intravenously (into a vein) to reduce damage to the heart muscle due to the reduced blood flow. Doing so may also improve blood flow to the kidney following the surgery.
Its use as a supplement is far less certain. Alternative practitioners believe that alpha-ketoglutaric acid can treat or prevent a wide variety of health conditions, including:
  • Cataracta
  • Boala renală cronică
  • Hepatomegalie (ficat mărit)
  • Toxemia intestinală
  • Aftă orală
  • osteoporoza
  • Tendinopatie
  • Infecții cu drojdie
Because of its role in releasing stored energy, alpha-ketoglutaric acid is often marketed as a sports performance supplement. Some proponents even assert that the supplement's antioxidant effects can slow aging.


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PubMed Central

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As is often the case with supplements that claim to treat multiple unrelated conditions, the evidence supporting these claims is weak. Some, like the supplement's "anti-aging" properties (based largely on a 2014 study involving nematode worms), border on the improbable.

Doza de acid alfa-cetoglutaric (328-50-7)

Alpha-ketoglutaric acid supplements are available in tablet, capsule, and powder formulations and can be readily found online or in stores specializing in dietary supplements.
There are no universal guidelines for the appropriate use of alpha-ketoglutaric acids. Supplements are typically sold in dosages ranging from 300 milligrams (mg) to 1,000 mg taken once daily with or without food. Doses of up to 3,000 mg have been used in studies with no adverse effects.

Acid alfa-cetoglutaric (328-50-7) posibile efecte secundare

Alpha-ketoglutaric acid is considered safe and well-tolerated. Studies investigating the effects of alpha-ketoglutaric acid reported few adverse symptoms after three years of use.
As a compound made from non-essential amino acids, alpha-ketoglutaric acid is not a substance on which you can readily overdose. Any excess in the body will either be excreted in urine or broken down into the basic amino acid building blocks for other purposes.


Sursa de încredere

PubMed Central

Baza de date foarte respectată de la National Institutes of Health
Accesați sursa

With that said, the safety of alpha-ketoglutaric acid in pregnant women, nursing mothers, and children has not been established. This includes children with rare metabolism disorders such as alpha-ketoglutarate dehydrogenase deficiency (in which alpha-ketoglutaric acid levels are abnormally elevated).

Pulbere de acid alfa-cetoglutaric de vânzare (De unde să cumpărați pulbere de acid alfa-cetoglutaric în vrac)

Compania noastră se bucură de relații pe termen lung cu clienții noștri, deoarece ne concentrăm pe serviciul pentru clienți și oferirea de produse excelente. Dacă sunteți interesat de produsul nostru, suntem flexibili cu personalizarea comenzilor pentru a se potrivi cu nevoile dvs. specifice, iar termenul nostru rapid pentru comenzi vă garantează că veți avea un gust excelent la timp. Ne concentrăm, de asemenea, pe servicii cu valoare adăugată. Suntem disponibili pentru întrebări și informații despre servicii pentru a vă sprijini afacerea.
We are an professional Alpha-Ketoglutaric Acid powder supplier for several years, we supply products with competitive price, and our product is of the highest quality and undergoes strict, independent testing to ensure that it is safe for consumption around the world.

De referinţă:

  1. Abrahams JP, Leslie AG, Lutter R, Walker JE. Structura la 2.8 A rezoluție a F1-ATPazei din mitocondriile inimii bovine. Natură. 1994; 370: 621-628. doi: 10.1038 / 370621a0.
  2. Alpers DH. Glutamina: datele susțin cauza suplimentării cu glutamină la om? Gastroenterologie. 2006; 130: S106 – S116. doi: 10.1053 / j.gastro.2005.11.049.
  3. Ashkanazi J, Carpertier Y, Michelsen C. Aminoacizi din mușchi și plasmă după leziuni. Ann Surg. 1980; 192: 78-85. doi: 10.1097 / 00000658-198007000-00014.